Criada por Dick Wolf, Matt Olmstead, Derek Haas e Michael Brandt, a história acompanha a vida e médicos e enfermeiras de um hospital de Chicago. Entre eles, a enfermeira April Sexton (Yaya DaCosta), que se envolve com Kelly (Taylor Kinney), personagem de Chicago Fire; Sharon Goodwin (S. Epatha Merkerson, de Lei & Ordem), diretora do hospital que não aprecia o sistema político no qual a instituição está inserido, mas está sempre aberta a ouvir as pessoas; Dr. Daniel Charles (Oliver Platt, de The Big C, Fargo), chefe da psiquiatria; o Dr. Will Halstead (Nick Gehlfuss); o Dr. Ethan (Brian Tee, de Crash) um novo residente do hospital que iniciou carreira no exército; e o Dr. Connor Bradhaw (Colin Donnell, de Arrow, The Affair).

8×01 – How Do You Begin to Count the Losses – (21/09/2022)
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8×02 – (Caught Between) The Wrecking Ball and the Butterfly – (28/09/2022)
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8×03 – Winning the Battle, but Still Losing the War – (05/10/2022)
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8×04 – The Apple Doesn’t Fall Far from the Teacher – (12/10/2022)
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8×05 – Yep, This is the World We Live In – (19/10/2022)
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8×06 – Mamma Said There Would Be Days Like This – (02/11/2022)
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8×07 – The Clothes Make The Man… Or Do They? – (09/11/2022)
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8×08 – Everyone’s Fighting A Battle You Know Nothing About – (16/11/2022)
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8×09 – Could Be The Start Of Something New – (07/12/2022)
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8×10 – A Little Change Might Do You Some Good – (04/01/2023)
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8×11 – It Is What It Is, Until It Isn’t – (11/01/2023)
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8×12 – We All Know What They Say About Assumptions – (18/01/2023)
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8×13 – It’s an Ill Wind That Blows Nobody Good – (15/02/2023)
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8×14 – On Days Like Today… Silver Linings Become Lifelines – (22/02/2023)
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8×16 – What You See Isn’t Always What You Get – (22/03/2023)

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